![]() Secretion from the adrenal medulla preceding the activation of the sympathetic nervous system functions to regulate blood pressure by contracting the smooth muscle in the vasculature (via alpha-1 receptors). The “fight or flight” response of the sympathetic nervous system is a direct result of the multisystem action of catecholamines. MAO and COMT catabolize norepinephrine and epinephrine to vanillylmandelic acid (VMA), and dopamine to homovanillic acid (HVA). Degradation of catecholamines to their metabolites occurs either by monoamine oxidase (MAO) located in the outer mitochondrial membrane of the cell and/or by catechol-o-methyltransferase (COMT) found within the cytosol of the cell. Glucocorticoids notably upregulate methyltransferase activity to increase epinephrine production. Norepinephrine can be secreted into the bloodstream or further modified by a methyltransferase to epinephrine (adrenaline) and then secreted. Dopamine may be secreted into the bloodstream or undergo further hydroxylation to norepinephrine (noradrenaline). Tyrosine undergoes hydroxylation via tyrosine hydroxylase to form DOPA, which then undergoes decarboxylation to dopamine. Catecholamine synthesis within the adrenal medulla is controlled by the serum concentration of the amino acid tyrosine.
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